4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

Base Information

Chemical Name:4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester
CAS No.:1254069-41-4
Molecular Formula:C₂₅H₃₀N₄O₃S
Molecular Weight:466.604
Hs Code.:

Synonyms:4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

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Chemical Property of 4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

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Technology Process of 4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

There total 8 articles about 4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1254069-38-9
3-(methylthio)-1-phenyl-1H-indazol-6-amine

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1254069-41-4
4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 15 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm100677s

Reference yield:

: 1254069-40-3
3-(methylthio)-6-nitro-1-phenyl-1H-indazole

: 1254069-41-4
4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 5% Pd(II)/C(eggshell); hydrogen / ethyl acetate / 0.8 h / 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 15 °C / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; triethylamine; HATU; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm100677s

Reference yield:

: 100-63-0
phenylhydrazine

: 1254069-41-4
4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 0.08 h / Reflux

2: hydrogenchloride; sodium nitrite / tetrahydrofuran; ethanol; water / Reflux

3: tetraphosphorus decasulfide / 5,5-dimethyl-1,3-cyclohexadiene / 0.67 h / Reflux

4: caesium carbonate / acetonitrile / 1 h / 10 °C

5: 5% Pd(II)/C(eggshell); hydrogen / ethyl acetate / 0.8 h / 20 °C

6: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 15 °C / Inert atmosphere

With hydrogenchloride; tetraphosphorus decasulfide; 5% Pd(II)/C(eggshell); hydrogen; caesium carbonate; triethylamine; HATU; sodium nitrite; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm100677s