N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide
• CAS No.: 1609064-35-8
• Molecular Formula: C₁₈H₁₉FN₂O₂S
• Molecular Weight: 346.425
• Mol file: 1609064-35-8.mol

Synonyms:N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide

There total 8 articles about N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-fluoro-1-methyl-1H-indol-3-yl)ethan-1-amine (910381-19-0) + p-toluenesulfonyl chloride (98-59-9) → N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide (1609064-35-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2015.05.065

Reference yield:

N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide (1024493-18-2) + methyl iodide (74-88-4) → N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide (1609064-35-8)

Guidance literature:

N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at -20 - 20 ℃;

DOI:10.1002/asia.201500865

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide (1609064-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -20 °C

2.2: -20 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/asia.201500865

upstream raw materials:

5-fluoro-1-methyl-1H-indole-3-carboxaldehyde

2-(5-fluoro-1-methyl-1H-indol-3-yl)ethan-1-amine

p-toluenesulfonyl chloride

5-fluoro-1H-indole

Downstream raw materials:

C₄₄H₅₃FN₂O₆S