N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide
• CAS No.: 1024493-18-2
• Molecular Formula: C₁₇H₁₇FN₂O₂S
• Molecular Weight: 332.399
• Mol file: 1024493-18-2.mol

Synonyms:N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

There total 1 articles about N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-fluorotryptamine (576-16-9) + p-toluenesulfonyl chloride (98-59-9) → N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide (1024493-18-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 24 ℃; for 4h;

DOI:10.1021/ja509893s

Reference yield: 92.0%

tert-butyl 2-methylbut-3-en-2-yl carbonate (861216-48-0) + N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide (1024493-18-2) → (±)-(3aS,8aR)-5-fluoro-3a-(2-methylbut-3-en-2-yl)-1-tosyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

Guidance literature:

N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide; With triethyl borane; potassium tert-butylate; In tetrahydrofuran; 1,4-dioxane; at 24 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (±)-9-(dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)-9H-carbazole; In tetrahydrofuran; 1,4-dioxane; at 24 ℃; for 0.166667h; Inert atmosphere;

tert-butyl 2-methylbut-3-en-2-yl carbonate; In tetrahydrofuran; 1,4-dioxane; at 24 ℃; for 1h; Reagent/catalyst; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ja509893s

Reference yield: 81.0%

N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide (1024493-18-2) + 1-((2-bromoallyl)sulfonyl)-4-methylbenzene → N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-methyl-N-(3-tosylprop-1-en-2-yl)benzenesulfonamide

Guidance literature:

With caesium carbonate; In acetonitrile; at 25 ℃; for 2h;

DOI:10.1039/d0cc06991d

upstream raw materials:

5-fluorotryptamine

p-toluenesulfonyl chloride

Downstream raw materials:

(E)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

C₂₉H₃₅FN₂O₆S

N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide