[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

Base Information

Chemical Name:[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate
CAS No.:117023-65-1
Molecular Formula:C₄H₄O₄*C₃₄H₃₃F₂NO₃
Molecular Weight:657.711
Hs Code.:

Synonyms:[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

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Chemical Property of [4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

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Technology Process of [4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

There total 5 articles about [4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 117022-50-1
[4-(3-chloropropoxy)phenyl](phenyl)methanone

: 117023-65-1
[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

Guidance literature:: With sodium carbonate; potassium iodide; 1) n-butanol, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-65-1
[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 65 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 117023-65-1
[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]phenyl]phenylmethanone fumarate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 65 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022