(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

Base Information

Chemical Name:(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester
CAS No.:1083429-77-9
Molecular Formula:C₃₁H₂₇F₃N₆O₄
Molecular Weight:604.588
Hs Code.:

Synonyms:(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

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Chemical Property of (3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

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Technology Process of (3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

There total 4 articles about (3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083430-08-3
5-(6-chloro-2-methyl-imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethyl-pyridin-2-ylamine

: 1083429-98-4
benzyl N-[3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]oxetan-3-yl]carbamate

: 1083429-77-9
(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 8h; Heating / reflux;

Reference yield:

: 1083430-01-6
[3-(4-bromo-phenoxymethyl)oxetan-3-yl]methanol

: 1083429-77-9
(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium chlorite / 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite / water; acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer

2: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / Heating / reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 8 h / Heating / reflux

With sodium chlorite; diphenyl phosphoryl azide; potassium acetate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; In ethanol; water; toluene; acetonitrile;

Reference yield:

: 1083430-00-5
3-(4-bromo-phenoxymethyl)-oxetane-3-carboxylic acid

: 1083429-77-9
(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

2: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / Heating / reflux

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 8 h / Heating / reflux

With diphenyl phosphoryl azide; potassium acetate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene;