5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Base Information

Chemical Name:5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine
CAS No.:1083429-76-8
Molecular Formula:C₂₃H₂₁F₃N₆O₂
Molecular Weight:470.454
Hs Code.:

Synonyms:5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

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Chemical Property of 5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

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Technology Process of 5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

There total 5 articles about 5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083429-77-9
(3-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-phenoxymethyl}-oxetan-3-yl)-carbamic acid benzyl ester

: 1083429-76-8
5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 18h; under 3750.38 Torr;

Reference yield:

: 1083430-00-5
3-(4-bromo-phenoxymethyl)-oxetane-3-carboxylic acid

: 1083429-76-8
5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

2: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / Heating / reflux

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 8 h / Heating / reflux

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 20 °C / 3750.38 Torr

With diphenyl phosphoryl azide; hydrogen; potassium acetate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1083430-01-6
[3-(4-bromo-phenoxymethyl)oxetan-3-yl]methanol

: 1083429-76-8
5-{6-[4-(3-amino-oxetan-3-ylmethoxy)-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium chlorite / 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite / water; acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer

2: diphenyl phosphoryl azide; triethylamine / toluene / 5 h / 100 °C

3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / Heating / reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 8 h / Heating / reflux

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 20 °C / 3750.38 Torr

With sodium chlorite; diphenyl phosphoryl azide; hydrogen; potassium acetate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;