Technology Process of 3-(4-bromo-phenoxymethyl)-oxetane-3-carboxylic acid
There total 3 articles about 3-(4-bromo-phenoxymethyl)-oxetane-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium permanganate; sodium hydroxide;
In
1,4-dioxane; water;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C
2: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer
With
sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide; Diethyl carbonate / ethanol / 4 h / Heating / reflux
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C
3: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 20 h / 20 - 77 °C / pH 7 / Aqueous phosphate buffer
With
potassium hydroxide; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; triphenylphosphine; Diethyl carbonate;
In
tetrahydrofuran; ethanol; acetonitrile;
![[3-(4-bromo-phenoxymethyl)oxetan-3-yl]methanol](/Databaselist/images/loading.webp)
