Technology Process of 3-(phenylethynyl)-5,6,7,8-tetrahydroquinolin-5-ol
There total 5 articles about 3-(phenylethynyl)-5,6,7,8-tetrahydroquinolin-5-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
tetrahydrofuran; methanol; water;
at -5 - 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; ammonium acetate / benzene / 7 h / Reflux
2.1: hydrogen bromide / ethanol; water
3.1: ethanol / 9 h / Reflux
4.1: triphenylphosphine; palladium diacetate; potassium carbonate / acetonitrile / 0.25 - 0.33 h / 20 °C / Inert atmosphere
4.2: 4 h / Reflux; Inert atmosphere
5.1: sodium tetrahydroborate / water; tetrahydrofuran; methanol / 1 h / -5 - 0 °C
With
ammonium acetate; sodium tetrahydroborate; hydrogen bromide; palladium diacetate; potassium carbonate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; water; acetonitrile; benzene;
4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen bromide / ethanol; water
2.1: ethanol / 9 h / Reflux
3.1: triphenylphosphine; palladium diacetate; potassium carbonate / acetonitrile / 0.25 - 0.33 h / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: sodium tetrahydroborate / water; tetrahydrofuran; methanol / 1 h / -5 - 0 °C
With
sodium tetrahydroborate; hydrogen bromide; palladium diacetate; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; water; acetonitrile;
3.1: |Sonogashira Cross-Coupling / 3.2: |Sonogashira Cross-Coupling;
