Technology Process of (rac)-5-methoxy-3-(phenylethynyl)-5,6,7,8-tetrahydroquinoline
There total 6 articles about (rac)-5-methoxy-3-(phenylethynyl)-5,6,7,8-tetrahydroquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(phenylethynyl)-5,6,7,8-tetrahydroquinolin-5-ol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 0.25h;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; palladium diacetate; potassium carbonate / acetonitrile / 0.25 - 0.33 h / 20 °C / Inert atmosphere
1.2: 4 h / Reflux; Inert atmosphere
2.1: sodium tetrahydroborate / water; tetrahydrofuran; methanol / 1 h / -5 - 0 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C
3.2: 0 - 20 °C
With
sodium tetrahydroborate; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; water; acetonitrile; mineral oil;
1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; ammonium acetate / benzene / 7 h / Reflux
2.1: hydrogen bromide / ethanol; water
3.1: ethanol / 9 h / Reflux
4.1: triphenylphosphine; palladium diacetate; potassium carbonate / acetonitrile / 0.25 - 0.33 h / 20 °C / Inert atmosphere
4.2: 4 h / Reflux; Inert atmosphere
5.1: sodium tetrahydroborate / water; tetrahydrofuran; methanol / 1 h / -5 - 0 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C
6.2: 0 - 20 °C
With
ammonium acetate; sodium tetrahydroborate; hydrogen bromide; palladium diacetate; sodium hydride; potassium carbonate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; water; acetonitrile; mineral oil; benzene;
4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;
