(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

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Chemical Name:(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester
CAS No.:131631-99-7
Molecular Formula:C₃₄H₃₇N₃O₇
Molecular Weight:599.684
Hs Code.:

Synonyms:(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

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Chemical Property of (Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

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Technology Process of (Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

There total 5 articles about (Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33844-21-2
2-nitro-4-methoxybenzoic acid

: 131631-99-7
(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

3: 79 percent / H₂ / 5percent Pd/C / ethanol

4: 93 percent / aq. NaHCO₃ / CH₂Cl₂

5: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With thionyl chloride; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 50424-96-9
4-methoxy-2-nitro-benzoyl chloride

: 131631-99-7
(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

2: 79 percent / H₂ / 5percent Pd/C / ethanol

3: 93 percent / aq. NaHCO₃ / CH₂Cl₂

4: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 131632-13-8
1-[1-(4-Methoxy-2-nitro-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

: 131631-99-7
(Benzyloxycarbonyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-amino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂ / 5percent Pd/C / ethanol

2: 93 percent / aq. NaHCO₃ / CH₂Cl₂

3: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.44.725