1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Base Information

Chemical Name:1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril
CAS No.:131632-12-7
Molecular Formula:C₃₀H₃₁N₃O₅
Molecular Weight:513.593
Hs Code.:

Synonyms:1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

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Chemical Property of 1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Chemical Property:

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Technology Process of 1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

There total 5 articles about 1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 131632-14-9
1-[1-(2-Amino-4-methoxy-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

: 131632-12-7
1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane;
DOI:10.1248/cpb.44.725

Reference yield:

: 33844-21-2
2-nitro-4-methoxybenzoic acid

: 131632-12-7
1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

3: 79 percent / H₂ / 5percent Pd/C / ethanol

4: 93 percent / aq. NaHCO₃ / CH₂Cl₂

With thionyl chloride; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 50424-96-9
4-methoxy-2-nitro-benzoyl chloride

: 131632-12-7
1-[1-(4-Methoxy-2-benzyloxycarbonylaminobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

2: 79 percent / H₂ / 5percent Pd/C / ethanol

3: 93 percent / aq. NaHCO₃ / CH₂Cl₂

With hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725