8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane
CAS No.:1403676-73-2
Molecular Formula:C₁₆H₂₁FO₅S
Molecular Weight:344.404
Hs Code.:

Synonyms:8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Suppliers and Price of 8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

There total 4 articles about 8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 398456-87-6
2-fluoro-4-(methanesulfonyl)phenol

: 147767-55-3
(1,4-dioxaspiro[4.5]dec-8-yl)methyl methanesulfonic acid

: 1403676-73-2
8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1403676-73-2
8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Inert atmosphere; Reflux

2.1: lithium borohydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

2.2: 0.5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With lithium borohydride; caesium carbonate; triethylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 23521-81-5,17159-82-9
(1,4-dioxaspiro[4.5]dec-8-yl)methanol

: 1403676-73-2
8-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;