2-(2-Bromo-5-fluorophenyl)acetaldehyde

Base Information

Chemical Name:2-(2-Bromo-5-fluorophenyl)acetaldehyde
CAS No.:905710-81-8
Molecular Formula:C₈H₆BrFO
Molecular Weight:217.037
Hs Code.:
DSSTox Substance ID:DTXSID101292734

Synonyms:2-(2-bromo-5-fluorophenyl)acetaldehyde;905710-81-8;(2-bromo-5-fluorophenyl)acetaldehyde;2-Bromo-5-fluorophenylacetaldehyde;SCHEMBL485713;CSZAWKYBHOEQQD-UHFFFAOYSA-N;DTXSID101292734;2-Bromo-5-fluorobenzeneacetaldehyde;AKOS013285977;EN300-1912726;A1-19107

Suppliers and Price of 2-(2-Bromo-5-fluorophenyl)acetaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Bromo-5-fluorophenyl)acetaldehyde

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:215.95861
Heavy Atom Count:11
Complexity:140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)CC=O)Br

Technology Process of 2-(2-Bromo-5-fluorophenyl)acetaldehyde

There total 7 articles about 2-(2-Bromo-5-fluorophenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 4009-98-7
(methoxymethyl)triphenylphosphonium chloride

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 905710-81-8
2-(2-bromo-5-fluorophenyl)acetaldehyde

Guidance literature:: (methoxymethyl)triphenylphosphonium chloride; 2-bromo-5-fluorobenzaldehyde; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

With water; hydrogenchloride; In tetrahydrofuran; for 8h; Heating / reflux;

Reference yield:

: 866029-28-9
2-(2-bromo-5-fluorophenyl)ethan-1-ol

: 905710-81-8
2-(2-bromo-5-fluorophenyl)acetaldehyde

: C₁₆H₁₂Br₂F₂O₂

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃;
DOI:10.3390/biom10091319

Reference yield:

: 739336-26-6
2-(2-bromo-5-fluorophenyl) acetic acid

: 905710-81-8
2-(2-bromo-5-fluorophenyl)acetaldehyde

: C₁₆H₁₂Br₂F₂O₂

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: chloro-trimethyl-silane / 0 - 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / Reflux

3: silica gel; pyridinium chlorochromate / dichloromethane / 20 °C

With sodium tetrahydroborate; chloro-trimethyl-silane; silica gel; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.3390/biom10091319