Technology Process of 2-((S)-6-((R)-4-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
There total 10 articles about 2-((S)-6-((R)-4-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate;
With
water; sodium hydroxide;
In
ethanol;
for 1h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 2 h
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere; Microwave irradiation
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate / toluene / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation
4: sodium hydroxide; water / ethanol / 1 h
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl-diazodicarboxylate; water; potassium acetate; caesium carbonate; triphenylphosphine; sodium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere; Microwave irradiation
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate / toluene / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation
3: sodium hydroxide; water / ethanol / 1 h
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium acetate; caesium carbonate; sodium hydroxide;
In
1,4-dioxane; ethanol; toluene;
