5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine

Base Information

• Chemical Name: 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine
• CAS No.: 852155-65-8
• Molecular Formula: C₃₂H₃₄N₂O₈
• Molecular Weight: 574.631
• Mol file: 852155-65-8.mol

Synonyms:5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine

Chemical Property of 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine

There total 2 articles about 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-methyluridine (2140-76-3) → 5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine (852155-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: pyridine; dmap / 20 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; In dimethyl sulfoxide;

DOI:10.1002/cbic.201900590

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 3,O2'-dimethyluridine (7103-27-7) → 5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine (852155-65-8)

Guidance literature:

With pyridine; dmap; at 20 ℃; Inert atmosphere;

DOI:10.1002/cbic.201900590

Reference yield: 88.0%

succinic acid anhydride (108-30-5) + 5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine (852155-65-8) → 5'-O-dimethoxytrityl-3'-O-succinyl-N3,2'-O-dimethyluridine

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1093/nar/gkz339

upstream raw materials:

2'-O-methyluridine

4,4'-dimethoxytrityl chloride

3,O^2'-dimethyluridine

Downstream raw materials:

5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite