(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

Base Information

Chemical Name:(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate
CAS No.:1369963-33-6
Molecular Formula:C₂₅H₂₆FNO₆S
Molecular Weight:487.549
Hs Code.:

Synonyms:(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

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Chemical Property of (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

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Technology Process of (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

There total 5 articles about (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-32-5
(2R)-4-(benzyloxy)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butyl benzoate

: 1369963-33-6
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-33-6
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

4: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

With pyridine; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-33-6
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-hydroxybutyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;