N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

Base Information

Chemical Name:N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide
CAS No.:1369963-35-8
Molecular Formula:C₂₆H₂₄F₄N₄O₅S
Molecular Weight:580.56
Hs Code.:

Synonyms:N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

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Chemical Property of N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

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Technology Process of N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

There total 7 articles about N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-34-7
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

: 1369963-35-8
N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-35-8
N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

4: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere

With pyridine; methanol; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-35-8
N-(3'-fluoro-4'-methoxybiphenyl-4-yl)-N-{(2R)-1-hydroxy-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butan-2-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere

With methanol; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;