O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine

Base Information

• Chemical Name: O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine
• CAS No.: 1370437-59-4
• Molecular Formula: C₂₁H₂₅F₃N₆O₅
• Molecular Weight: 498.462

Synonyms:O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine

Chemical Property of O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine

There total 4 articles about O₆-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl alcohol (1370437-58-3) + 1‐(2‐amino‐9H‐purin‐6‐yl)‐1‐methylpyrrolidin‐1‐ium chloride → O6-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine (1370437-59-4)

Guidance literature:

(3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl alcohol; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

1‐(2‐amino‐9H‐purin‐6‐yl)‐1‐methylpyrrolidin‐1‐ium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1039/c2ob25231g

Reference yield:

ethyl 3-bromomethylbenzoate (62290-17-9) → O6-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine (1370437-59-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

1.2: 3 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

3.1: triethylamine / ethanol / 5 h / 20 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C

4.2: 3 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c2ob25231g

Reference yield:

ethyl 3-((2-(2-(2-azidoethoxy)ethoxy)ethoxy)methyl)benzoate (1370437-57-2) → O6-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine (1370437-59-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: triethylamine / ethanol / 5 h / 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 3 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1039/c2ob25231g

upstream raw materials:

ethyl 3-((2-(2-(2-azidoethoxy)ethoxy)ethoxy)methyl)benzoate

(3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl alcohol

ethyl 3-bromomethylbenzoate

2-[2-(2-azidoethoxy)ethoxy]ethanol

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