1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Base Information

Chemical Name:1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine
CAS No.:1426833-61-5
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:

Synonyms:1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Suppliers and Price of 1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

There total 8 articles about 1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1426833-60-4
1-[3-O-benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine

: 1426833-61-5
1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Guidance literature:: 1-[3-O-benzyl-2-deoxy-2-vinyl-β-D-ribo-pentofuranosyl]thymine; With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2.5h;

formaldehyd; With sodium hydroxide; In 1,4-dioxane; for 15h;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 1426833-61-5
1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 7 steps

1.1: p-toluenesulfonic acid monohydrate; sodium iodide / acetone / 4 h / 55 °C

2.1: pyridine / 20 °C / Inert atmosphere

3.1: triethylamine; dmap / toluene / 1.17 h / 20 °C / Inert atmosphere

4.1: 2,2'-azobis(isobutyronitrile); hexamethyldistannane / benzene / 5 h / Reflux

4.2: 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / -10 °C / Inert atmosphere; Cooling with ice

5.2: 19 h / -10 - 4 °C

6.1: hydrogenchloride / ethyl acetate / 2 h / 0 °C / Cooling with ice

7.1: Dess-Martin periodane / dichloromethane / 2.5 h / 0 °C

7.2: 15 h

With pyridine; hydrogenchloride; dmap; 2,2'-azobis(isobutyronitrile); p-toluenesulfonic acid monohydrate; hexamethyldistannane; sodium hydride; Dess-Martin periodane; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; toluene; mineral oil; benzene;

Reference yield:

: 1426833-56-8
1-[5-O-(4-methoxytrityl)-2-deoxy-2-iodo-3-(dimethyl)vinylsilyl-β-D-ribo-pentofuranosyl]-thymine

: 1426833-61-5
1-[3-O-benzyl-4-C-hydroxymethyl-2-deoxy-2-vinyl-3-β-ribo-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2'-azobis(isobutyronitrile); hexamethyldistannane / benzene / 5 h / Reflux

1.2: 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / -10 °C / Inert atmosphere; Cooling with ice

2.2: 19 h / -10 - 4 °C

3.1: hydrogenchloride / ethyl acetate / 2 h / 0 °C / Cooling with ice

4.1: Dess-Martin periodane / dichloromethane / 2.5 h / 0 °C

4.2: 15 h

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); hexamethyldistannane; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; mineral oil; benzene;