tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

Base Information

Chemical Name:tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate
CAS No.:1354792-39-4
Molecular Formula:CH₂O₂*C₁₈H₂₈N₂O₃
Molecular Weight:366.458
Hs Code.:

Synonyms:tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

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Chemical Property of tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

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Technology Process of tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

There total 1 articles about tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 64-18-6
formic acid

: 540510-97-2
4-((dimethylamino)methyl)-2-methylphenol

: 141699-58-3
3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester

: 1354792-39-4
tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

Guidance literature:: 4-((dimethylamino)methyl)-2-methylphenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.666667h; Cooling with ice; Inert atmosphere;

3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; Inert atmosphere;

formic acid; In water; acetonitrile;

Reference yield: 78.0%

: 1354792-39-4
tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

: 1310-73-2
sodium hydroxide

: 1354792-40-7
1-(4-(azetidin-3-yloxy)-3-methylphenyl)-N,N-dimethylmethanamine

Guidance literature:: tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate; With hydrogenchloride; methanol; at 20 ℃;

sodium hydroxide; In water; pH=10;

Reference yield:

: 1354792-39-4
tert-Butyl 3-(4-((dimethylamino)methyl)-2-methylphenoxy)azetidine-1-carboxylate formate

: 1354791-36-8
(3-{4-[(dimethylamino)methyl]-2-methyl-phenoxy}azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; methanol / 20 °C

1.2: pH 10

2.1: ethanol / 3.25 h / 120 °C / Sealed tube

With hydrogenchloride; methanol; In ethanol;