3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid
CAS No.:1373277-66-7
Molecular Formula:C₃₁H₂₅FN₄O₅
Molecular Weight:552.562
Hs Code.:

3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

Synonyms:3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

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Chemical Property of 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

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Technology Process of 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

There total 6 articles about 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-88-6
tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

: 1373277-66-7
3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 1373277-66-7
3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 20 h / 80 °C

2: sodium hypochlorite / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium hypochlorite; sodium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 1373277-66-7
3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisobutyl-tert-butoxyaluminum hydride / tetrahydrofuran / 3 h / 0 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: sodium hypochlorite / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium hypochlorite; lithium diisobutyl-tert-butoxyaluminum hydride; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;