methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Base Information

Chemical Name:methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate
CAS No.:1373278-85-3
Molecular Formula:C₂₆H₂₇FN₂O₅
Molecular Weight:466.509
Hs Code.:

Synonyms:methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

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Chemical Property of methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

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Technology Process of methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

There total 4 articles about methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

: 122699-51-8
3-methylenecyclobutanecarboxylic acid tert-butyl ester

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: 3-methylenecyclobutanecarboxylic acid tert-butyl ester; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 60 ℃; for 3h; Inert atmosphere;

methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.; With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.2: 12 h / 60 °C / Inert atmosphere

With N,N-dimethyl-aniline; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.2: 12 h / 60 °C / Inert atmosphere

With N,N-dimethyl-aniline; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;