tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Base Information

Chemical Name:tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate
CAS No.:1373278-88-6
Molecular Formula:C₃₅H₃₃FN₄O₅
Molecular Weight:608.669
Hs Code.:

tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Synonyms:tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

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Chemical Property of tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

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Technology Process of tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

There total 5 articles about tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61841-34-7
2-isopropenylbenzoxazole

: 1373278-87-5
tert-butyl 3-((3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

: 1373278-88-6
tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: With sodium hypochlorite; In dichloromethane; at 20 ℃;

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 1373278-88-6
tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 20 h / 80 °C

2: sodium hypochlorite / dichloromethane / 20 °C

With sodium hypochlorite; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 1373278-88-6
tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisobutyl-tert-butoxyaluminum hydride / tetrahydrofuran / 3 h / 0 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: sodium hypochlorite / dichloromethane / 20 °C

With sodium hypochlorite; lithium diisobutyl-tert-butoxyaluminum hydride; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;