Calcium folinate

Base Information

• Chemical Name: Calcium folinate
• CAS No.: 1492-18-8
• Molecular Formula: C20H21N7O7^.Ca
• Molecular Weight: 511.507
• Hs Code.: 29362900
• Mol file: 1492-18-8.mol

Synonyms:Calcium leucovorin;Calcium folinate ;Calcium leucovorin;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]-5,5-dihydroxy-pentanoic acid;Folinic acid-SF, calcium salt;L-Glutamic acid,N-[4-[[(2-amino-5-formyl- 1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)- methyl]amino]benzoyl]-,calcium salt (1:1);Uzel;Folinic acid calcium;Calcium Folinate(Leucovorin calcium);Calcium folinate anhydrous;Leucovorin Calcium;

Chemical Property of Calcium folinate

Chemical Property:

• Appearance/Colour: Pale yellow crystalline powder
• Melting Point: 240-250oC
• PSA: 198.10000
• LogP: 1.41100
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent).

Purity/Quality:

99.5% up ^*data from raw suppliers

Calcium Folinate Hydrate >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 26-36-36/37-22-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1.? Calcium Folinate is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.);2. Calcium Folinate can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate. 3.? The megaloblastic anemia caused by folic acid deficiency. 4.? In combination with fluorouracil, it is used for the treatment of advanced colon cancer and rectal cancer.It is used for the rescue of the toxicity reaction caused by excessive amount of aminopterin and methotrexate as well as being used for the treatment of giant red blood cell anemia.The efficacy of folate can offset the effects of folic acid antagonists. The folic acid antagonists rely on binding to folic acid dehydrogenase (DHFR), thereby preventing folate from converting to folic acid. Medically, after the chemotherapy of methotrexate, the calcium folinate can be used to reduce methotrexate toxicity. Calcium folinate can be used to enhances the cytotoxic effect of 5-fluorouracil in anticancer fields. antianemic, antidote to folic acid antagonists.Calcium folinate (folinic acid, calcium leucovorin, tetrahydrofolate) can be used in the management of methotrexate overdose and to reduce the toxicity of high-dose methotrexate chemotherapy.Calcium folinate is a reduced form of folic acid, which bypasses the inhibition of dihydrofolate reductase by methotrexate.Calcium folinate also has a role in combination with fluorouracil in the treatment of bowel cancer, where its use enhances the effect of fluorouracil by inhibition of thymidilate synthase. Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
• Therapeutic Function: Antidote (folic acid antagonists), Antianemic

Technology Process of Calcium folinate

There total 6 articles about Calcium folinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

<5,10-Metheno-5,6,7,8-tetrahydrofolsaeure>(1+)Cl(1-) → calcium folinate (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

With sodium hydroxide; phosphate buffer pH₇; for 5h; Heating;

Reference yield: 48.0%

(6R)-5,10-methylylidenetetrahydrofolic acid chloride (65981-90-0) → (6S)-5-formyltetrahydrofolic acid calcium salt (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

With water; calcium chloride; Heating;

DOI:10.1016/S0040-4020(01)87409-3

Reference yield: 42.7%

(6S,S)-5,6,7,8-tetrahydrofolic acid (135-16-0,15582-28-2,29347-89-5,71963-69-4,74708-38-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → calcium 5-methyl-(6S)-tetrahydrofolic acid 6(S)-5-methyl tetrahydrofolate + (6S)-5-formyltetrahydrofolic acid calcium salt (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

(6S,S)-5,6,7,8-tetrahydrofolic acid; formaldehyd; With sodium hydroxide; In water; for 0.5h; pH=9;

With potassium borohydride; In water; at 15 ℃; for 4h; pH=9;

DOI:10.1007/s11164-012-0751-2

upstream raw materials:

(6R)-5,10-methylylidenetetrahydrofolic acid chloride

(6S,S)-5,6,7,8-tetrahydrofolic acid

formaldehyd

Refernces

• 1、 Zhou, Minghao,Hong, Mei,Xiao, Guomin. "A novel synthetic method for preparation of some folates". . p. 2211 - 2218. Retrieved 2013/06/05.
• 2、 Owens, Jonathan,Rees, Lilias,Suckling, Colin J.,Wood, Hamish C. S.. "The Preparation of the (6R)- and (6S)-Diastereoisomers of 5-Formyltetrahydrofolate (Leucovorin)". . p. 871 - 876. Retrieved 2007/10/02.