(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

Base Information

Chemical Name:(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide
CAS No.:1412892-68-2
Molecular Formula:C₂₅H₂₉N₃O₄
Molecular Weight:435.523
Hs Code.:

Synonyms:(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

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Chemical Property of (E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

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Technology Process of (E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

There total 5 articles about (E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1236289-29-4
(E)-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

: 109-89-7
diethylamine

: 1412892-68-2
(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.2174/157340612802084252

Reference yield:

: 1236289-19-2
(E)-ethyl 3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylate

: 1412892-68-2
(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; dimethyl sulfoxide / Inert atmosphere

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.2174/157340612802084252

Reference yield:

: 1-(4'-methoxyphenyl)-2-(1''-(3,'''4'''-dimethoxyphenyl)ethylidene)hydrazine

: 1412892-68-2
(E)-N,N-diethyl-3-(1'-(4''-methoxyphenyl)-3'-(3''',4'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,3,5-trichloro-2,4,6-triazine / 2 h / 20 °C / Inert atmosphere

2: acetonitrile / Reflux; Inert atmosphere

3: sodium hydroxide / ethanol; dimethyl sulfoxide / Inert atmosphere

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

With 1,3,5-trichloro-2,4,6-triazine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile; 2: |Wittig Olefination;
DOI:10.2174/157340612802084252