N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1439879-09-0
Molecular Formula:C₂₅H₁₇Cl₂F₂N₃O₄
Molecular Weight:532.33
Hs Code.:

Synonyms:N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 12 articles about N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225278-69-2
5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl amine

: 1345855-09-5
4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

: 1439879-09-0
N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; Inert atmosphere; Cooling with ice;

Reference yield:

: 524955-92-8
2-chloro-5-fluoro-4-nitrophenol

: 1439879-09-0
N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; zinc / methanol; tetrahydrofuran / 0.5 h / 15 - 25 °C

2: potassium carbonate / dimethyl sulfoxide / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere; Cooling with ice

With potassium carbonate; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1225278-68-1
2-chloro-4-(2-chloro-5-fluoro-4-nitrophenoxy)pyridine

: 1439879-09-0
N-(5-chloro-4-((2-chloropyridin-4-yl)oxy)-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; zinc / methanol; tetrahydrofuran / 1 h / 15 - 25 °C

2: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere; Cooling with ice

With ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane;