2-Chloro-5-fluorophenol

Base Information

Chemical Name:2-Chloro-5-fluorophenol
CAS No.:3827-49-4
Molecular Formula:C6H4ClFO
Molecular Weight:146.549
Hs Code.:2908199090
DSSTox Substance ID:DTXSID80369147
Wikidata:Q72451063
Mol file:3827-49-4.mol

Synonyms:2-chloro-5-fluorophenol;3827-49-4;MFCD00042524;2-chloro-5-fluorphenol;SCHEMBL70547;DTXSID80369147;CMQOZIKIOASEIN-UHFFFAOYSA-N;2-Chloro-5-fluorophenol, AldrichCPR;AKOS005063843;CS-W004781;PS-8945;AC-25971;BP-20171;SY022945;AM20050147;FT-0635028;EN300-115639;J-508831

Suppliers and Price of 2-Chloro-5-fluorophenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-5-fluorophenol
500mg
$ 65.00

TRC
2-Chloro-5-fluorophenol
100mg
$ 45.00

SynQuest Laboratories
2-Chloro-5-fluorophenol 98%
5 g
$ 35.00

SynQuest Laboratories
2-Chloro-5-fluorophenol 98%
100 g
$ 395.00

SynQuest Laboratories
2-Chloro-5-fluorophenol 98%
25 g
$ 140.00

Strem Chemicals
2-Chloro-5-fluorophenol, min. 97%
25g
$ 134.00

Strem Chemicals
2-Chloro-5-fluorophenol, min. 97%
5g
$ 34.00

Matrix Scientific
2-Chloro-5-fluorophenol 95+%
25g
$ 52.00

Matrix Scientific
2-Chloro-5-fluorophenol 95+%
100g
$ 170.00

Crysdot
2-Chloro-5-fluorophenol 98%
500g
$ 594.00

Total 74 raw suppliers

Chemical Property of 2-Chloro-5-fluorophenol

Chemical Property:

Appearance/Colour:clear colourless to pale yellow liquid
Vapor Pressure:19.5mmHg at 25°C
Refractive Index:1.524-1.526
Boiling Point:189.3 °C at 760 mmHg
PKA:7.50±0.10(Predicted)
Flash Point:68.3 °C
PSA：20.23000
Density:1.408 g/cm³
LogP:2.18470
Storage Temp.:Sealed in dry,Room Temperature
Water Solubility.:slightly soluble
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:145.9934706
Heavy Atom Count:9
Complexity:99.1

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-5-fluorophenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn,Xi
Statements: 36/37/38-20/21/22-22
Safety Statements: 36/37/39-26

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)O)Cl

Technology Process of 2-Chloro-5-fluorophenol

There total 3 articles about 2-Chloro-5-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 372-20-3
3-fluorophenol

: 3827-49-4
2-chloro-5-fluoro-phenol

Guidance literature:: With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride; In toluene; at 0 ℃; for 4h; regioselective reaction; Darkness;
DOI:10.1021/acscatal.8b00327

Reference yield: 73.0%

: 372-20-3
3-fluorophenol

: 3827-49-4
2-chloro-5-fluoro-phenol

: 348-60-7
4-chloro-3-fluorophenol

Guidance literature:: With N-chloro-succinimide; C₂₄H₂₀F₁₂N₄OS; In chloroform-d1; at 20 ℃; for 9h; regioselective reaction;
DOI:10.1021/acs.orglett.6b02650

Reference yield:

: 372-19-0
meta-fluoroaniline

: 3827-49-4
2-chloro-5-fluoro-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: aqueous sulfuric acid; sodium nitrite / Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat auf 190grad

2: chlorine

With sulfuric acid; chlorine; sodium nitrite;
DOI:10.1021/ja01510a021