ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate
• CAS No.: 1449301-78-3
• Molecular Formula: C₁₄H₁₂FNO₃
• Molecular Weight: 261.253
• Mol file: 1449301-78-3.mol

Synonyms:ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Chemical Property of ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

There total 3 articles about ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-Triazine (290-87-9) + ethyl 4-(2-fluorophenyl)-3-oxobutanoate (221121-35-3) → ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1449301-78-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 85 ℃; for 4h;

Reference yield:

2-(2-fluorophenyl)acetyl chloride (451-81-0) → ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1449301-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3.5 h / 20 °C / Cooling with ice

2.1: Reflux

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 120 °C

3.2: Reflux

With triethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;

DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1621689-64-2) → ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1449301-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Reflux

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 120 °C

2.2: Reflux

In 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.ejmech.2014.07.033

upstream raw materials:

1,3,5-Triazine

ethyl 4-(2-fluorophenyl)-3-oxobutanoate

2-(2-fluorophenyl)acetyl chloride

5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide

5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylic acid

ethyl 5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate