4-(2-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-(2-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER
• CAS No.: 221121-35-3
• Molecular Formula: C₁₂H₁₃FO₃
• Molecular Weight: 224.232
• Mol file: 221121-35-3.mol

Synonyms:ethyl 4-(2-fluorophenyl)-3-oxobutanoate

Chemical Property of 4-(2-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ethyl4-(2-fluorophenyl)-3-oxobutanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER

There total 3 articles about 4-(2-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1621689-64-2) → ethyl 4-(2-fluorophenyl)-3-oxobutanoate (221121-35-3)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

2-(2-fluorophenyl)acetyl chloride (451-81-0) → ethyl 4-(2-fluorophenyl)-3-oxobutanoate (221121-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3.5 h / 20 °C / Cooling with ice

2: Reflux

With triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

ethyl potassium malonate (6148-64-7) + 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone (221121-28-4) → ethyl 4-(2-fluorophenyl)-3-oxobutanoate (221121-35-3)

Guidance literature:

With triethylamine; magnesium chloride; Yield given; Multistep reaction; 1.) CH₃CN, RT, 2 h, 2.) CH₃CN, a) RT, overnight, b) reflux, 2 h;

DOI:10.1021/jm980260f

upstream raw materials:

ethyl potassium malonate

2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone

2-(2-fluorophenyl)acetyl chloride

ethanol

Downstream raw materials:

N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide

5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylic acid

ethyl 5-(2-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

6-(2-fluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Refernces

• 1、 Mai, Antonello,Artico, Marino,Sbardella, Gianluca,Massa, Silvio,Novellino, Ettore,Greco, Giovanni,Loi, Anna Giulia,Tramontano, Enzo,Marongiu, Maria Elena,La Colla, Paolo. "5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin- 4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives". . p. 619 - 627. Retrieved 2007/10/03.