5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

• Chemical Name: 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS No.: 1621689-64-2
• Molecular Formula: C₁₄H₁₃FO₅
• Molecular Weight: 280.253
• Mol file: 1621689-64-2.mol

Synonyms:5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Chemical Property of 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 2 articles about 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

cycl-isopropylidene malonate (2033-24-1) + (2-fluorophenyl)acetic acid (451-82-1) → 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1621689-64-2)

Guidance literature:

With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; Reflux;

DOI:10.1021/acs.orglett.5b00520

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 2-(2-fluorophenyl)acetyl chloride (451-81-0) → 5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1621689-64-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3.5h; Cooling with ice;

DOI:10.1016/j.ejmech.2014.07.033

Reference yield: 83.0%

5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1621689-64-2) + 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (762240-92-6) → 4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione

Guidance literature:

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride; With 4-methyl-morpholine; In ethyl acetate; at 40 ℃;

5-(2-(2-fluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione; In ethyl acetate; Reflux;

DOI:10.1021/acs.orglett.5b00520

upstream raw materials:

cycl-isopropylidene malonate

2-(2-fluorophenyl)acetyl chloride

(2-fluorophenyl)acetic acid

Downstream raw materials:

ethyl 5-(2-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

ethyl 4-(2-fluorophenyl)-3-oxobutanoate