Technology Process of phenyl 2-(benzyloxy)-3,4-bis(chloromethyl)-5-fluoro-6-methylbenzoate
There total 10 articles about phenyl 2-(benzyloxy)-3,4-bis(chloromethyl)-5-fluoro-6-methylbenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride; tetrabutyl-ammonium chloride;
In
1,2-dichloro-ethane;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
2.1: bromine; acetic acid / 2 h / 20 °C
3.1: potassium carbonate / acetone / 3 h / 0 - 50 °C
4.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C
4.2: 1 h / -78 - -20 °C
5.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C
6.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -78 - 0 °C
6.2: 2 h / 0 - 40 °C
7.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 2 h / 80 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; thionyl chloride; tetrabutyl-ammonium chloride; bromine; isopropylmagnesium chloride; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C
1.2: 1 h / -78 - -20 °C
2.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C
3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -78 - 0 °C
3.2: 2 h / 0 - 40 °C
4.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 2 h / 80 °C
With
methanol; sodium tetrahydroborate; n-butyllithium; thionyl chloride; tetrabutyl-ammonium chloride; isopropylmagnesium chloride; diisopropylamine; lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
