phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

Base Information

Chemical Name:phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate
CAS No.:1253799-55-1
Molecular Formula:C₂₇H₂₈FNO₃
Molecular Weight:433.523
Hs Code.:

Synonyms:phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

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Chemical Property of phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

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Technology Process of phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

There total 11 articles about phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1253799-53-9
phenyl 2-(benzyloxy)-3,4-bis(chloromethyl)-5-fluoro-6-methylbenzoate

: 75-64-9
tert-butylamine

: 1253799-55-1
phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; at 110 ℃;

Reference yield:

: 220901-72-4
3-fluoro-6-methoxy-2-methylbenzoic acid

: 1253799-55-1
phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C

1.2: 12 h / 25 °C

2.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C

3.1: bromine; acetic acid / 2 h / 20 °C

4.1: potassium carbonate / acetone / 3 h / 0 - 50 °C

5.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

5.2: 1 h / -78 - -20 °C

6.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

7.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -78 - 0 °C

7.2: 2 h / 0 - 40 °C

8.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 2 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 110 °C

With methanol; sodium tetrahydroborate; n-butyllithium; thionyl chloride; oxalyl dichloride; tetrabutyl-ammonium chloride; bromine; isopropylmagnesium chloride; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1253799-47-1
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-formyl-6-methylbenzoate

: 1253799-55-1
phenyl 4-(benzyloxy)-2-tert-butyl-7-fluoro-6-methylisoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / -78 - 0 °C

2.2: 2 h / 0 - 40 °C

3.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 2 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 110 °C

With methanol; sodium tetrahydroborate; thionyl chloride; tetrabutyl-ammonium chloride; isopropylmagnesium chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; 1,2-dichloro-ethane;