FMOC-HYDRAZIDE HCL

Base Information

• Chemical Name: FMOC-HYDRAZIDE HCL
• CAS No.: 35661-51-9
• Molecular Formula: C15H14N2O2
• Molecular Weight: 254.288
• Hs Code.: 29280000
• Mol file: 35661-51-9.mol

Synonyms:9-Fluorenylmethoxycarbonylhydrazine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazine;

Chemical Property of FMOC-HYDRAZIDE HCL

Chemical Property:

• Melting Point: ~170 °C (dec.)
• Boiling Point: 485.8 °C at 760 mmHg
• PKA: 10.21±0.20(Predicted)
• Flash Point: 247.6 °C
• PSA: 64.35000
• Density: 1.26 g/cm³
• LogP: 3.49000
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

9-Fluorenylmethyl Carbazate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-38-37-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 9-Fluorenylmethyl Carbazate is a reagent for the sensitive fluorogenic derivatization of carbohydrates.

Technology Process of FMOC-HYDRAZIDE HCL

There total 6 articles about FMOC-HYDRAZIDE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) → N-(9-fluorenylmethyloxycarbonyl)hydrazine (35661-51-9)

Guidance literature:

With hydrazine; In water; acetonitrile; at 0 - 20 ℃; for 14h;

DOI:10.1021/jo300311q

Reference yield: 86.0%

11-aminoundecanoic acid (2432-99-7,25587-80-8,84029-94-7) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → N-(9-fluorenylmethyloxycarbonyl)hydrazine (35661-51-9)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; pH=9; Reflux;

DOI:10.1021/bc500392x

Reference yield: 46.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → N-(9-fluorenylmethyloxycarbonyl)hydrazine (35661-51-9)

Guidance literature:

With hydrazine hydrate; In water; acetonitrile; at 20 ℃;

DOI:10.1039/c9ob01133a

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

9-Fluorenylmethanol

C₂₀H₂₂N₂O₄

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid 9H-fluoren-9-ylmethyl ester

4-[(9H-Fluoren-9-ylmethoxycarbonyl)-hydrazonomethyl]-benzoic acid methyl ester

5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-fluoro)-phenylpentanoic acid

5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-bromo)-phenylpentanoic acid