5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid

Base Information

• Chemical Name: 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid
• CAS No.: 1621254-16-7
• Molecular Formula: C₃₅H₃₂F₇NO₅
• Molecular Weight: 679.632

Synonyms:5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid

Chemical Property of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid

There total 10 articles about 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate (1621254-14-5) → 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid (1621254-16-7)

Guidance literature:

With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 50 ℃;

Reference yield:

C7H5FINO3 → 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid (1621254-16-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Microwave irradiation

2.1: diisobutylaluminium hydride / dichloromethane

3.1: Dess-Martin periodane / dichloromethane

4.1: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

6.1: hydrogen / methanol

7.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

7.2: 1 h / 20 °C

8.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

9.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;

Reference yield:

C18H22FNO5 → 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylic acid (1621254-16-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / dichloromethane

2.1: Dess-Martin periodane / dichloromethane

3.1: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

5.1: hydrogen / methanol

6.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

6.2: 1 h / 20 °C

7.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 50 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 7.1: |Suzuki Coupling;

upstream raw materials:

C₁₆H₁₈FNO₄

(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

(4S,5R)-3-((2-(5-amino-4-fluoro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one

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