methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

Base Information

Chemical Name:methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate
CAS No.:1621254-14-5
Molecular Formula:C₃₆H₃₄F₇NO₅
Molecular Weight:693.658
Hs Code.:

methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

Synonyms:methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

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Chemical Property of methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

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Technology Process of methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

There total 9 articles about methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1621255-76-2
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(4-fluoro-5-iodo-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1621254-14-5
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: C₇H₅FINO₃

: 1621254-14-5
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Microwave irradiation

2.1: diisobutylaluminium hydride / dichloromethane

3.1: Dess-Martin periodane / dichloromethane

4.1: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

6.1: hydrogen / methanol

7.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

7.2: 1 h / 20 °C

8.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;

Reference yield:

: C₁₈H₂₂FNO₅

: 1621254-14-5
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2'-fluoro-4'-methoxybiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / dichloromethane

2.1: Dess-Martin periodane / dichloromethane

3.1: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

5.1: hydrogen / methanol

6.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 2 h / 20 °C

6.2: 1 h / 20 °C

7.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 7.1: |Suzuki Coupling;