(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Base Information

Chemical Name:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol
CAS No.:1621255-75-1
Molecular Formula:C₂₇H₂₉F₇N₂O₄
Molecular Weight:578.527
Hs Code.:

Synonyms:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Suppliers and Price of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

There total 5 articles about (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1152029-16-7
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol

: 1621256-15-2
C₁₆H₁₈FNO₄

: 1621255-75-1
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: C₇H₅FINO₃

: 1621255-75-1
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Microwave irradiation

2: diisobutylaluminium hydride / dichloromethane

3: Dess-Martin periodane / dichloromethane

4: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; In 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

: C₁₈H₂₂FNO₅

: 1621255-75-1
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane

2: Dess-Martin periodane / dichloromethane

3: sodium cyanoborohydride; acetic acid / dichloromethane / 1 h / 20 °C

With diisobutylaluminium hydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; In dichloromethane;