N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide

Base Information

• Chemical Name: N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide
• CAS No.: 1430223-96-3
• Molecular Formula: C₂₃H₁₇N₃O₃S₂
• Molecular Weight: 447.538
• Mol file: 1430223-96-3.mol

Synonyms:N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide

Chemical Property of N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide

There total 3 articles about N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

thiophene-2-carbaldehyde (98-03-3) + 4-(p-toluenesulfonylamino)acetophenone (5317-94-2) + ethyl 2-cyanoacetate (105-56-6) → N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide (1430223-96-3)

Guidance literature:

With ammonium acetate; In ethanol; for 5h; Reflux;

DOI:10.1080/15257770.2013.775449

Reference yield:

p-aminobenzophenone (99-92-3) → N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide (1430223-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / Reflux

2: ammonium acetate / ethanol / 5 h / Reflux

With pyridine; ammonium acetate; In ethanol;

DOI:10.1080/15257770.2013.775449

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-(4-(5-cyano-6-oxo-4-(4-thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzensulfonamide (1430223-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / Reflux

2: ammonium acetate / ethanol / 5 h / Reflux

With pyridine; ammonium acetate; In ethanol;

DOI:10.1080/15257770.2013.775449

upstream raw materials:

p-aminobenzophenone

thiophene-2-carbaldehyde

4-(p-toluenesulfonylamino)acetophenone

ethyl 2-cyanoacetate

Downstream raw materials:

N-(4-(5-cyano-6-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-(thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzenesulfonamide

N-(4-(5-cyano-6-oxo-4-(thien-2-yl)-1-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzenesulfonamide

N-(4-(5-cyano-6-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyloxy)-4-(thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzenesulfonamide

N-(4-(5-cyano-6-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)-4-(thien-2-yl)-1,6-dihydropyridin-2-yl)phenyl)-4-methylbenzenesulfonamide