N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide

Base Information

• Chemical Name: N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide
• CAS No.: 223526-93-0
• Molecular Formula: C₁₇H₁₉NO₃S
• Molecular Weight: 317.409
• Mol file: 223526-93-0.mol

Synonyms:N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide

Chemical Property of N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide

There total 8 articles about N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide (90312-02-0) + allyl bromide (106-95-6) → N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide (223526-93-0)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 22h; Inert atmosphere;

DOI:10.1016/j.tet.2017.06.039

Reference yield: 89.0%

ethyl 2-(2-propenyl-4-toluenesulfonylamino)benzoate (223526-92-9) → N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide (223526-93-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(99)00150-1

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide (223526-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / chloroform / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With pyridine; potassium carbonate; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.5b03499

upstream raw materials:

ethyl 2-(2-propenyl-4-toluenesulfonylamino)benzoate

ethyl 2-(4-methylphenylsulfonamido)benzoate

p-toluenesulfonyl chloride

2-ethoxycarbonylaniline