223526-92-9

Upstream product

• 223526-78-1 ethyl 2-(4-methylphenylsulfonamido)benzoate 
• 106-95-6 allyl bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 87-25-2 2-ethoxycarbonylaniline 
• 118-92-3 anthranilic acid 

Downstream Products

• 223526-93-0 N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide 
• 324057-41-2 2-{[(4-methylphenyl)sulfonyl](2-propen-1-yl)amino}benzoic acid 
• 223526-79-2 N-(2-formylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide 

Relevant academic research and scientific papers

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

An intramolecular azomethine ylide-alkene cycloaddition approach to pyrrolo[3,2-c]quinolines-synthesis of a C2-truncated martinelline model

The hexahydropyrrolo[3,2-c]quinoline core found in the Martinella alkaloids was constructed through an intramolecular [3+2] azomethine ylide-alkene cycloaddition. Some chemical manipulations of the tricycle are reported.

An approach to the pyrroloquinoline core of martinelline and martinellic acid

An expedient method for the assembly of the pyrroloquinoline skeleton found in the martinelline alkaloids using a [3+2] cycloaddition of an azomethine ylide and an alkene has been developed.