2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Base Information

• Chemical Name: 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone
• CAS No.: 83520-19-8
• Molecular Formula: C₂₇H₂₃Cl₂N₅O₄
• Molecular Weight: 552.417
• Mol file: 83520-19-8.mol

Synonyms:2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Chemical Property of 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

There total 10 articles about 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.2%

3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline (83520-09-6) → 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone (83520-19-8)

Guidance literature:

With acetic acid; for 3h; Heating;

DOI:10.1021/jm00354a015

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone (83520-19-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hexamethylphosphoric acid triamide / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 3.75 g / HCl gas / diethyl ether / 0 °C

3: 2.) AcOH / 1.) EtOH, RT, 8 d, 2.) benzene, reflux, 1.5 h

4: AcOH / ethanol / Ambient temperature

5: 56.2 percent / AcOH / 3 h / Heating

With hydrogenchloride; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol;

DOI:10.1021/jm00354a015

Reference yield:

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone (83520-19-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

3: 81.7 percent / dimethylformamide / Ambient temperature

4: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

5: hexamethylphosphoric acid triamide; acetonitrile / Ambient temperature

6: 56.2 percent / AcOH / 3 h / Heating

With hydrogen bromide; hydrazine hydrate; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00354a015

upstream raw materials:

3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline

N-(benzyloxycarbonyl)glycyl chloride

<<(benzyloxycarbonyl)glycyl>amino>acetonitrile

2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

Downstream raw materials:

2',5-dichloro-2-(3-glycylaminomethyl-5-methyl-4H-1,2,4-triazol-4-yl)-benzophenone