2(1H)-Pyrimidinone, 4-amino-5-nitro- (9CI)

Base Information

• Chemical Name: 2(1H)-Pyrimidinone, 4-amino-5-nitro- (9CI)
• CAS No.: 69099-99-6
• Molecular Formula: C4H4N4O3
• Molecular Weight: 156.101
• Mol file: 69099-99-6.mol

Synonyms:2(1H)-Pyrimidinone,4-amino-5-nitro- (9CI);Cytosine, 5-nitro- (6CI,7CI);5-Nitrocytosine;NSC266148;

Chemical Property of 2(1H)-Pyrimidinone, 4-amino-5-nitro- (9CI)

Chemical Property:

• Vapor Pressure: 7.43E-13mmHg at 25°C
• Melting Point: >360℃
• Refractive Index: 1.798
• Boiling Point: 553.4 °C at 760 mmHg
• Flash Point: 288.5 °C
• PSA: 117.59000
• Density: 2.02 g/cm³
• LogP: 0.36470

Purity/Quality:

99% ^*data from raw suppliers

5-Nitrocytosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyrimidinone, 4-amino-5-nitro- (9CI)

There total 4 articles about 2(1H)-Pyrimidinone, 4-amino-5-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Cytosine (71-30-7) → 4-amino-5-nitropyrimidin-2(1H)-one (69099-99-6)

Guidance literature:

With sulfuric acid; nitric acid; at 80 ℃; for 18h;

DOI:10.1016/0040-4020(95)00080-R

Reference yield:

2-ethylsulfanyl-pyrimidin-4-ylamine (54308-63-3) → 4-amino-5-nitropyrimidin-2(1H)-one (69099-99-6)

Guidance literature:

With sulfuric acid; nitric acid;

Reference yield:

2-ethoxy-5-nitro-3H-pyrimidin-4-one (99968-75-9) → 4-amino-5-nitropyrimidin-2(1H)-one (69099-99-6)

Guidance literature:

With ethanol; ammonia;

upstream raw materials:

2-ethylsulfanyl-pyrimidin-4-ylamine

2-ethoxy-5-nitro-3H-pyrimidin-4-one

Cytosine

Downstream raw materials:

2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

5-nitrobarbituric acid

4,5-diamino-1,2-dihydropyrimidin-2-one