2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

Base Information

• Chemical Name: 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS No.: 122336-54-3
• Molecular Formula: C₃₀H₂₄N₄O₁₀
• Molecular Weight: 600.541
• Mol file: 122336-54-3.mol

Synonyms:2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property of 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

There total 3 articles about 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 4-amino-5-nitropyrimidin-2(1H)-one (69099-99-6) → 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (122336-54-3)

Guidance literature:

4-amino-5-nitropyrimidin-2(1H)-one; With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; for 36h; Reflux;

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; With tin(IV) chloride; In dichloromethane; acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2013.03.005

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + (5-nitro-2-trimethylsilanyloxy-pyrimidin-4-yl)-trimethylsilanyl-amine (914801-60-8) → 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (122336-54-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; acetonitrile; at 23 ℃; for 3h;

DOI:10.1021/jm060872x

Reference yield:

→ 2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (122336-54-3)

Guidance literature:

Di-(5-nitro-cytosin)-quecksilber, 2,3,5-Tri-O-benzoyl-D-ribofuranosylchlorid, sd. Toluol;

DOI:10.1021/jo01061a058

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

(5-nitro-2-trimethylsilanyloxy-pyrimidin-4-yl)-trimethylsilanyl-amine

4-amino-5-nitropyrimidin-2(1H)-one

Downstream raw materials:

2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate

2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

2-((benzoyloxy)methyl)-5-(2-oxo-8-(p-tolyl)-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

2-((benzoyloxy)methyl)-5-(8-(4-methoxyphenyl)-2-oxo-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate