methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

Base Information

Chemical Name:methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate
CAS No.:724445-33-4
Molecular Formula:C₁₇H₁₅BrN₂O₅
Molecular Weight:407.221
Hs Code.:

Synonyms:methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

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Chemical Property of methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

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Technology Process of methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

There total 8 articles about methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 724445-31-2
methyl 3-(benzoyloxy)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

: 724445-33-4
methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 75 ℃; for 1h;
DOI:10.1016/j.tetlet.2007.07.043

Reference yield:

: 724445-29-8
methyl-3-(benzyloxy)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

: 724445-33-4
methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 678 mg / hydrogen / Pd/C / methanol / 3 h

2: 77 percent / Et₃N; DMAP / tetrahydrofuran / 2 h / 20 °C

3: 70 percent / NBS; dibenzoylperoxide / CCl₄ / 1 h / 75 °C

With dmap; N-Bromosuccinimide; hydrogen; triethylamine; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane;
DOI:10.1016/j.tetlet.2007.07.043

Reference yield:

: 1-(benzyloxy)piperidin-2-imine hydrochloride

: 724445-33-4
methyl 3-(benzoyloxy)-9-bromo-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / hydrogen / Pd/C / methanol / 3 h

2: 83 percent / Et₃N / CHCl₃ / 1 h / 20 °C

3: 42 percent / o-xylene / 5 h / Heating

4: 77 percent / Et₃N; DMAP / tetrahydrofuran / 2 h / 20 °C

5: 70 percent / NBS; dibenzoylperoxide / CCl₄ / 1 h / 75 °C

With dmap; N-Bromosuccinimide; hydrogen; triethylamine; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; o-xylene;
DOI:10.1016/j.tetlet.2007.07.043