2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Base Information

Chemical Name:2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
CAS No.:1069136-76-0
Molecular Formula:C₂₉H₃₃Cl₂N₃O₂
Molecular Weight:526.506
Hs Code.:

Synonyms:2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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Chemical Property of 2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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Technology Process of 2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

There total 10 articles about 2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 109-65-9
1-bromo-butane

: 932739-13-4
1-(2,4-dichlorophenyl)-2-(4-hydroxyphenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

: 1069136-76-0
2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Heating / reflux;

Reference yield:

: 1001018-36-5
4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

: 1069136-76-0
2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / toluene / 2 h / 60 °C

2: potassium carbonate / acetonitrile / 6 h / Heating / reflux

With potassium carbonate; trifluoroacetic acid; In toluene; acetonitrile;

Reference yield:

: 71365-42-9
3-(piperidin-1-ylamino)-propionic acid methyl ester

: 1069136-76-0
2-(4-butoxyphenyl)-1-(2,4-dichlorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

3.1: acetic acid / water / 1 h / Heating / reflux

4.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

5.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 5 °C

5.2: 0.25 h

6.1: trifluoroacetic acid / toluene / 2 h / 60 °C

7.1: potassium carbonate / acetonitrile / 6 h / Heating / reflux

With sodium hydride; potassium carbonate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;