2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Base Information

• Chemical Name: 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane
• CAS No.: 1310949-94-0
• Molecular Formula: C₁₂H₁₆BClO₃
• Molecular Weight: 254.521
• Mol file: 1310949-94-0.mol

Synonyms:2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Chemical Property of 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Chemical Property:

• Boiling Point: 359.8±32.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

There total 2 articles about 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,2-Dimethyl-1,3-propanediol (126-30-7) + 3-chloro-4-methoxyphenylboronic acid (175883-60-0) → 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (1310949-94-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.9b02236

Reference yield: 72.0%

→ 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (1310949-94-0)

Guidance literature:

Reference yield: 70.0%

potassium 2-(2-nitrophenyl)acetate (1316859-98-9) + 2-(3-chloro-4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (1310949-94-0) → C14H12ClNO3

Guidance literature:

With copper diacetate; at 35 ℃; for 12h; Sealed tube;

DOI:10.1002/anie.201800829

upstream raw materials:

2,2-Dimethyl-1,3-propanediol

3-chloro-4-methoxyphenylboronic acid