trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Base Information

Chemical Name:trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one
CAS No.:137242-86-5
Molecular Formula:C₂₂H₂₂N₂O₄S
Molecular Weight:410.494
Hs Code.:

Synonyms:trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Suppliers and Price of trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

There total 3 articles about trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 130369-82-3
potassium acetate 2-(1,3-dioxoisoindolin-2-yl)

: 137242-80-9
S-methyl N-(4-methoxyphenyl)-butanethioimidate

: 137242-86-5
trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Guidance literature:: With O-phenyl phosphorodichloridate; triethylamine; In dichloromethane; 1) 0 deg C, 2 h, 2) rt, overnight;
DOI:10.1016/S0040-4020(01)82327-9

Reference yield:

: 35274-21-6
N-(4-methoxyphenyl)butanethioamide

: 137242-86-5
trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, 1 h, rt

2: 84 percent / Et₃N, phenyl dichlorophosphate / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) rt, overnight

With sodium hydride; O-phenyl phosphorodichloridate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)82327-9

Reference yield:

: 5421-40-9
N-(4-methoxyphenyl)butyramide

: 137242-86-5
trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / 2,4-bis-(p-methoxyphenyl)-1,3-dithiadiphosphetane-2,4-disulfide / hexamethylphosphoric acid triamide / 100 °C

2: 1) NaH / 1) THF, 1 h, rt

3: 84 percent / Et₃N, phenyl dichlorophosphate / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) rt, overnight

With Lawessons reagent; sodium hydride; O-phenyl phosphorodichloridate; triethylamine; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4020(01)82327-9