4'-Methoxybutyranilide

Base Information

• Chemical Name: 4'-Methoxybutyranilide
• CAS No.: 5421-40-9
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.246
• Hs Code.: 2924299090
• European Community (EC) Number: 226-539-3
• NSC Number: 6880
• UNII: 52TLY97VJD
• DSSTox Substance ID: DTXSID10202558
• Nikkaji Number: J218.001D
• Wikidata: Q83075857
• Mol file: 5421-40-9.mol

Synonyms:4'-Methoxybutyranilide;N-(4-methoxyphenyl)butanamide;5421-40-9;Butanamide, N-(4-methoxyphenyl)-;4//'-Methoxybutyranilide;52TLY97VJD;NSC-6880;EINECS 226-539-3;AI3-18518;p-Butyranisidide;NSC6880;4/'-Methoxybutyranilide;UNII-52TLY97VJD;SCHEMBL8277402;DTXSID10202558;N-(4-methoxy-phenyl)-butanamide;NSC 6880;STL255956;AKOS002943920;AO-548/40055355;W-110037

Chemical Property of 4'-Methoxybutyranilide

Chemical Property:

• Boiling Point: 365.8°Cat760mmHg
• Flash Point: 175°C
• PSA: 38.33000
• Density: 1.076g/cm³
• LogP: 2.50680
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 174

Purity/Quality:

98% ^*data from raw suppliers

N-(4-methoxyphenyl)butanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(=O)NC1=CC=C(C=C1)OC

Technology Process of 4'-Methoxybutyranilide

There total 14 articles about 4'-Methoxybutyranilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

[4-(benzylideneamino)phenyl]methanol (783-08-4) + butyryl chloride (141-75-3) → N-(4-methoxyphenyl)butyramide (5421-40-9) + benzaldehyde (100-52-7)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield: 92.0%

N-butyryl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamide + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)butyramide (5421-40-9) + N-(4-chlorophenyl)-4-nitrobenzenesulfonamide (16937-03-4)

Guidance literature:

With potassium carbonate; In water; at 80 ℃; for 1h; Green chemistry;

DOI:10.1515/znb-2015-0076

Reference yield: 92.0%

1-(4-methoxyphenyl)butanone oxime (423115-90-6) → N-(4-methoxyphenyl)butyramide (5421-40-9)

Guidance literature:

With tricarallylic acid; at 160 ℃; for 0.0833333h; Inert atmosphere; neat (no solvent);

DOI:10.3184/174751911X557296

upstream raw materials:

butanoic acid anhydride

4-methoxy-aniline

butyryl chloride

[4-(benzylideneamino)phenyl]methanol

Downstream raw materials:

N-<(tert-butoxycarbonyl)methyl>-N-(4-methoxyphenyl)butanamide

trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one

trans-1-(4-methoxyphenyl)-3-phenoxy-4-(n-propyl)-4-methylthio-azetidin-2-one

S-methyl N-(4-methoxyphenyl)-butanethioimidate