N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

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Chemical Name:N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid
CAS No.:1056271-56-7
Molecular Formula:C₂₃H₂₈Br₃N₇O₅
Molecular Weight:722.231
Hs Code.:

Synonyms:N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

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Chemical Property of N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

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Technology Process of N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

There total 8 articles about N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 939437-05-5
diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

: 1056271-56-7
N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

Guidance literature:: diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate; With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; water;
DOI:10.1016/j.ejmech.2008.04.017

Reference yield:

: 76822-61-2
2,4-Diamino-6-(hydroxymethyl)pyrido<3,2-d>pyrimidine

: 1056271-56-7
N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; platinum(IV) oxide hydrate; hydrogen / ethanol; water / 24 h / 20 °C / 2250.23 Torr

2: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

3: silica gel / 24 h / 20 °C

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

5: bromine / tetrahydrofuran / 7 h

6: sodium hydroxide / tetrahydrofuran; water / 1 h

With hydrogenchloride; platinum(IV) oxide hydrate; hydrogen; bromine; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604

Reference yield:

: 1392197-18-0
(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methanol

: 1056271-56-7
N-[4-{(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino}-3-bromobenzoyl]-L-glutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

2: silica gel / 24 h / 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

4: bromine / tetrahydrofuran / 7 h

5: sodium hydroxide / tetrahydrofuran; water / 1 h

With bromine; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604