diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate
CAS No.:939437-03-3
Molecular Formula:C₂₇H₃₇N₇O₅
Molecular Weight:539.635
Hs Code.:

Synonyms:diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Suppliers and Price of diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

There total 6 articles about diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 939436-99-4
diethyl N-[4-[[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

: 106-95-6
allyl bromide

: 939437-03-3
diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2008.04.017

Reference yield:

: 76822-61-2
2,4-Diamino-6-(hydroxymethyl)pyrido<3,2-d>pyrimidine

: 939437-03-3
diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; platinum(IV) oxide hydrate; hydrogen / ethanol; water / 24 h / 20 °C / 2250.23 Torr

2: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

3: silica gel / 24 h / 20 °C

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

With hydrogenchloride; platinum(IV) oxide hydrate; hydrogen; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604

Reference yield:

: 1392197-18-0
(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methanol

: 939437-03-3
diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

2: silica gel / 24 h / 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

With silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604