diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate
CAS No.:939437-05-5
Molecular Formula:C₂₇H₃₆Br₃N₇O₅
Molecular Weight:778.339
Hs Code.:

Synonyms:diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

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Chemical Property of diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

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Technology Process of diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

There total 8 articles about diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939437-06-6
diethyl N-[4-[[2-(2,4-diamino-5-allyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]-3-bromo-benzoyl]-L-glutamate

: 939437-05-5
diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

Guidance literature:: With bromine; In tetrahydrofuran; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2008.04.017

Reference yield:

: 76822-61-2
2,4-Diamino-6-(hydroxymethyl)pyrido<3,2-d>pyrimidine

: 939437-05-5
diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; platinum(IV) oxide hydrate; hydrogen / ethanol; water / 24 h / 20 °C / 2250.23 Torr

2: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

3: silica gel / 24 h / 20 °C

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

5: bromine / tetrahydrofuran / 7 h

With hydrogenchloride; platinum(IV) oxide hydrate; hydrogen; bromine; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604

Reference yield:

: 1392197-18-0
(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methanol

: 939437-05-5
diethyl N-[4-[[2-(2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]3-bromo-benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetra-(n-butyl)ammonium iodide; p-toluenesulfonyl chloride; sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C

2: silica gel / 24 h / 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h

4: bromine / tetrahydrofuran / 7 h

With bromine; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055604